1. Temperature: Increasing temperature generally increases solubility, as more molecules of a solute can be dissolved in a solvent at higher temperatures.
2. Pressure: Increasing pressure can increase the solubility of a gas in a liquid.
3. Nature of the Solvent: The polarity of the solvent can affect the solubility of a solute. Polar solvents tend to dissolve polar solutes better than nonpolar solvents. Nonpolar solvents dissolve non polar solutes better than polar solvents.
4. Nature of the Solute: The polarity of the solute can also affect its solubility. Polar solutes tend to dissolve better in polar solvents, while nonpolar solutes tend to dissolve better in nonpolar solvents.