Thyroxine deficiency can lead to a number of different disabilities, including:

- Fatigue and tiredness
 - Weight gain
 - Intolerance to cold
 - Difficulty concentrating and learning
 - Depression
 - Irregular or absent menstruation
 - Dry skin
 - Hair loss
 - Muscle weakness
 - Elevated cholesterol levels
 - Constipation
 - Slow heart rate
 - Goitre (enlarged thyroid gland)